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OTC Medications: A Pharmacy Tech Guide

Key over-the-counter drug categories relevant to the PTCE.

February 15, 2026

Why OTC Medications Matter

Over-the-counter medications do not require a prescription, but pharmacy technicians still need to be familiar with common OTC products. Patients frequently ask questions about OTC options, and some OTC medications have interactions with prescription drugs or are regulated behind the counter.

Pain and Fever Relievers

Acetaminophen (Tylenol) and ibuprofen (Advil, Motrin) are among the most common OTC medications. Naproxen (Aleve) is another OTC anti-inflammatory option. Technicians should know that these belong to different classes: acetaminophen is an analgesic, while ibuprofen and naproxen are NSAIDs (nonsteroidal anti-inflammatory drugs).

Allergy Medications

Antihistamines like cetirizine (Zyrtec), loratadine (Claritin), and diphenhydramine (Benadryl) are commonly purchased OTC. The newer antihistamines like cetirizine and loratadine are less likely to cause drowsiness compared to diphenhydramine.

Acid Reducers

Proton pump inhibitors like omeprazole (Prilosec OTC) and H2 blockers like famotidine (Pepcid) are available over the counter. Antacids like calcium carbonate (Tums) provide quick relief for occasional heartburn.

Behind-the-Counter Products

Some products are kept behind the pharmacy counter without requiring a prescription. Pseudoephedrine-containing products are the most notable example, requiring identification and quantity limits for purchase due to the Combat Methamphetamine Epidemic Act.

Exam Relevance

The PTCE may include questions about common OTC medications, their drug classes, and any special handling requirements. Understanding the distinction between prescription, OTC, and behind-the-counter status is important for both the exam and daily practice.

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